Nutrihuang.com TCM and Hepatomegaly for OEM
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Traditional Chinese Medicine for Hepatomegaly has Scientific Backing

Your liver performs hundreds of important functions — from aiding absorption of food to removing toxic substances from your body. Normally, an adult liver is about the size of a small football. Sometimes, however, the liver becomes enlarged. This is known as hepatomegaly. An enlarged liver isn't a disease. It's a sign of an underlying problem, such as hepatitis, congestive heart failure or cancer. Treatment of an enlarged liver depends on the cause.

Overview

The lower edge of the liver normally comes just to the lower edge of the ribs (costal margin) on the right side. In its normal state, the edge of the liver is thin and firm, and it cannot be palpated (felt with the finger tips) below the edge of the costal margin. An enlarged liver usually causes no signs or symptoms. If the liver enlarges quickly, it may be tender to the touch. A markedly enlarged liver may cause abdominal pain or fullness. If the cause of enlargement affects liver function, it may lead to yellowing of the skin (jaundice). The diagnosis must be confirmed by an imaging study of the liver.

General classes of causes include infection (viral, bacterial, or parasitic), malignancy (cancer or tumors), anemias, storage diseases, heart failure, congenital heart disease, toxins, and metabolic disturbances.

Common Causes:

  • Alcohol abuse

  • Nonalcoholic fatty liver disease

  • Hepatitis

  • Heart failure

  • Liver cancer Infections such as mononucleosis

  • Excessive iron in the body (hemochromatosis)

  • Blood disorders such as leukemia 

  • Hereditary fructose intolerance  

  • Glycogen storage disease

  • Primary biliary cirrhosis

  • Reye's syndrome

Symptoms

Many people with hepatomegaly may have minor symptoms loss of energy and tiredness in the early stages of the disease but as the disease progresses to an advance stage a person may experience the following symptoms:

  • Exhaustion
  • Fatigue
  • Loss of appetite
  • Nausea
  • Weakness
  • Weight loss
  • Abdominal pain

Treatment

Hepatomegaly can be cured. Treatment depends on the cause of hepatomegaly. For example, abstaining from alcohol treats hepatomegaly caused by alcohol abuse. In all cases, regardless of the cause, appropriate medication can be taken to treat the underlying cause.

Thanks to growing trust in herbal treatments survival rates have improved over the years. Herbal formulations to treat various types of liver problems have proven to be safe and very effective without any side effects. When allopathic science failed, more and more people have to turn to alternative source. It was desperation that saves them.

Scientific research has showed and proven beyond a shadow of doubt the validity of these beliefs that herbs like Radix Rehmannia Glutinosa, Fructus Zanthii, Radix Glycyrrhiza Glabra, Flos Lonicera Japonica, Radix Scutellaria Baicalensis and Herba Artemisiae Scoparia have successfully been used to treat chronic hepatitis problems:

  • Chronic hepatitis

  • Cleanse and protect the liver

  • Hepatomegaly (enlarged liver and spleen)

  • Increase red blood cell production

  • Nourishes the blood

  • Protects the liver

  • Treats toxic effects caused by virus and bacteria

  • Improves function of the spleen

Radix Rehmannia Glutinosa: Clinical research by western scientists have shown that Chinese Rehmanniae Radix can prevent an inducement of impediment in the peripheral microcirculation of various chronic diseases through the improvement of hemorheology (blood flow). 12826

Glycyrrhiza Glabra:

This was part of the report sent by Dr. Minh-Tri Nguyen to Dr. Gueůnaešl Rodier, Director, Department of Communicable Disease Surveillance and Response (CSR), WHO Headquarter  "Viruses are chemical particles having the ability to replicate only inside a living cell. Each virus particle or viron consist of a core of a single nucleic acid DNA or RNA surrounding by a protein coat and some cases by carbohydrates or lipids. Since viruses have no cellular organization, they have not cellular organism, have no nucleus, no cytoplasm and no surrounding  membrane, they are not alive but rather obligate parasites at genetic level (require a host cell in order to replicate). That is why antibiotics (anti=against, bio life) cannot kill coronaryviruses and consequently there is no possible vaccine for colds, influenza or SARS. Coronaryvirus (virus from Latin = poison) can be only counter-acted or neutralized by specific antidote herbs, which are highly suitable for human body." In the report to WHO he sighted that Radix Glycyrrhizae can be used for detoxification: neutralizes the poison produce by viruses and bacteria by action of  Glycyrrhizic acid C42 H62 O16

Licorice root extract has been used in Japan for more than twenty years as a treatment for chronic hepatitis. Results from randomized clinical trials using licorice root have shown a significant reduction of serum amino-transferase and a significant improvement in liver histology.11,12

11 Van Rossum TG, Vulto AG, de Man RA, Brouwer JT, Schalm SW. Review Article: glycyrrhizin as a potential treatment for chronic hepatitis C. Aliment Pharmacol Ther 1998 Mar; 12(3): 199-205.
12 Yamamura Y, Kotaki H, Tanaka N, Aikawa T, Sawada Y, Iga T. The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and chronically carbon-tetrachloride intoxicated rats. Biopharm Drug Dispos 1997 Nov;18(8):717-25.

1) Clinical research by western scientists have shown that glycyrrhizin has inhibitory effects on immune-mediated cytotoxicity against hepatocytes and on nuclear factor (NF)-kappa B, which activates genes encoding inflammatory cytokines in the liver and can be used to treat hepatitis. 87634

2) Clinical research by western scientists have shown that this herb has strong anticarcinogenic capability. Aflatoxin B(1) (AFB(1)) causes oxidative stress and ROS formation via metabolic activation of AFB(1). Glycyrrhizic acid (GA) has been reported to have antioxidative properties. 67692

3) Clinical research by western scientists have shown that the decrease of elevated transaminase levels by glycyrrhizin in patients with chronic viral hepatitis is mediated in part by inhibition of immune-mediated cytotoxicity against hepatocytes. 42643

4) Clinical research by western scientists have shown that glycyrrhizin suppressed the intracellular transport of HBsAg at the trans-Golgi area after O-linked glycosylation and before its sialylation. Glycyrrhizin, a major component of a herb (licorice), has been widely used to treat chronic hepatitis B in Japan. 14808

5) Clinical research by western scientists have shown that Glycyrrhizin, an aqueous extract of licorice root, has anti-inflammatory activity and can be used for the treatment of chronic viral hepatitis.  Research showed that glycyrrhizin may prevent tissue injury caused by MAC not only in chronic hepatitis but in many autoimmune and inflammatory diseases. 92245

6) Clinical research by western scientists in a double blind placebo test have shown that active compounds in licorice root can be used to help prevent and treat chronic hepatitis (liver inflammation). 941500

7) Clinical research by western scientists have shown that (R)-4-(3,4-Dihydro-8,8-dimethyl)-2H,8H-benzo[1,2-b:3,4-b']dipyran-3yl)-1,3-benzenediol (glabridin), a flavonoid present in licorice extract, is known to have antimicrobial, anti-inflammatory, and cardiovascular protective activities. 312:1187

8) Clinical research by western scientists have shown that isoflavans from G. glabra were shown to be effective in protecting liver mitochondrial function against oxidative stresses. 14953

Scutellaria baicalensis:

1) Clinical research by western scientists have shown that saikosaponin-a, -d, baicalin from  Scutellaria baicalensis are potent antitumor components. 28;86(1):91-5

2) Clinical research by western scientists have shown that the flavones of Scutellaria baicalensis showed remarkable inhibitory effects on skin tumor. 40(2):531-3.

3) Clinical research by western scientists have shown that Scutellaria baicalensis' components, baicalein, baicalin, and wogonin, may become an attractive and promising treatment for bladder cancer because of its strong antioxidant effect.  55(6):951-5

4) Clinical research by western scientists have shown that Scutellaria baicalensis has anti-inflammatory and anti-cancer properties. Research showed that Scutellaria baicalensis selectively and effectively inhibits cancer cell growth in vitro and in vivo and can be an effective chemotherapeutic agent for HNSCC. Inhibition of PGE2 synthesis via suppression of COX-2 expression may be responsible for its anticancer activity.  4037-40

5) Western scientists has proven that Scutellaria baicalensis Georgi can be used to induce liver regeneration. Research showed that SbG stimulates hepatocyte growth via activation of the NF-B pathway and induces TGF-ß1 gene expression through the Kupffer cell–hepatocyte interaction, which subsequently results in the inhibition of SbG-stimulated hepatocyte growth. 231:444

6) Clinical research by western scientists have shown that this herb has strong anti-oxidant (anti-cancer) properties. Research showed that most of the anticancer activities of S. baicalensis can be recapitulated with four purified constituents that function in part through inhibition of the androgen receptor signaling pathway. 390539

7) Clinical research by western scientists has shown that Scutellaria baicalensis have anti-inflammatory functions, high scavenging activity and protects liver and red blood cells from lipid peroxidation. Research showed that extract of Scutellaria baicalensis showed inhibitory actions on aminopyrine N-demethylase and xanthine oxidase activities as well as an pro-oxidant effect observed in the Fe3+-EDTA-H2O2 system. 60151

Herba Artemisiae Scorparia:

1) Clinical research by western scientists have shown that this herb is effective for treating liver diseases. Research showed that scoparone decreases the production of the inflammatory mediators such as NO and PGE2 in macrophages by inhibiting iNOS and COX-2 expression. 203-8 

2) Another group of scientists wrote "these data indicate that the plant artemisia scoparia is hepatoprotective and validate the folkloric use of this plant in liver damage". The scientists wrote "the pretreatment of rats with plant extract (150 mg/kg) significantly lowered (P < 0.01), the respective serum GOT and GPT levels to 93 +/- 05 and 27 +/- 03 IU/l, indicating hepatoprotective action." 41001

3) Clinical research by western scientists has shown that the plant artemisia scoparia is hepatoprotective and validate the folkloric use of this plant for treating liver problems". Research demonstrated that the inhibition of scoparone on LPS-induced TF expression in HUVECs may mediate by the mechanisms suppressing superoxide anion formation and TF transcription. 72379

4) Clinical research by western scientists have shown that artemisia scoparia has strong hepatoprotective function. Research demonstrated that AC may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells. 75739

5) Clinical research by western scientists have shown that this herb is strong hepatoprotective function against drug-induced hepatotoxicity. Research showed that rutin (20 mg/kg) was able to prevent the CCl(4)-induced rise in serum enzymes and that it also prevented the CCl(4)-induced prolongation in pentobarbital sleeping time confirming its hepatoprotectivity. 90212

6) Clinical research by western scientists have shown that this herb has strong hepatoprotective function against drug-induced hepatotoxicity. Research showed that the plant extract (150 mg/kg) lowered significantly the respective serum GOT and GPT levels to 85 +/- 11 and 23 +/- 06.5. 12519

7) Clinical research by western scientists have shown that this herb has strong hepatoprotective function against chemical-induced hepatotoxicity. 33139

8) Clinical research by western scientists have shown that this herb has strong hepatoprotective function against chemical-induced hepatotoxicity. Research showed that DA-9601 effectively protected rat liver tissues against the DMN-induced hepatic fibrosis. Antioxidant could be considered as a supplementary therapeutic for alleviating the hepatic fibrosis. 06248

9) Clinical research by western scientists have shown that scoparone of Artemisia capillaris has immune-enhancing activity. Research showed that scoparone may inhibit the expression of chemokines (IL-8 and MCP-1) in PMA-stimulated U937 cells and a potential mechanism of scoparone may be inhibition of NF-kappaB activation, which is linked to inhibition of NF-kappaB subunits (NF-kappaB(1) p50, RelA p65, and c-Rel p75) translocation via suppression of IkappaBalpha phosphorylation. 37638

Thanks to growing trust in herbal treatments survival rates have improved over the years. Herbal formulations to treat various types of hepatitis problems has proven to be safe and very effective without any side effects. When allopathic science failed, more and more people have to turn to trustworthy alternative source. It was desperation that saves them.

 

Eminent scientists of well-known universities have scientifically researched and  proved the incredible efficacy of these natural herbs used by us. We only bring to you formulas that can say something for themselves.

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