Nutrihuang.com TCM and Stroke for OEM
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Traditional Chinese Medicine for Hypertension has Scientific Backing

What causes Stroke?

Chinese medicine theory recognizes four main pathological factors (agents) of stroke: Wind, Fire, Phlegm, and Stasis. Other contributing factors that cause stroke to happen are: - (1) prolonged negative lifestyle such as emotional stress, overwork, poor diet, and excessive sexual activity. (2) Unhealed diseases:

Lifestyle factors:

1.   Working long hours under stressful conditions without adequate rest

2.   Physical overwork including excessive, strenuous sports activities

3.   Emotional strain; irregular eating habits

4.   Excessive consumption of fats, dairy products, greasy or fried foods, sugar, or alcohol

5.   Excessive sexual activity (what constitutes “excessive” sexual activity depends on the age and general physical condition of the individual).

Disease factors:

High blood pressure — High blood pressure (140/90 mm Hg or higher) is the most important risk factor for stroke. It usually has no specific symptoms and no early warning signs. That’s why everybody should have their blood pressure checked regularly.

Tobacco use — Cigarette smoking is a major, preventable risk factor for stroke. The nicotine and carbon monoxide in tobacco smoke reduce the amount of oxygen in your blood. They also damage the walls of blood vessels, making clots more likely to form. Using some kinds of birth control pills combined with smoking cigarettes greatly increases stroke risk.

Diabetes mellitus — Diabetes is defined as fasting plasma glucose (blood sugar) of 126 mg/dl or more measured on two occasions. While diabetes is treatable, having it stilt increases a person’s risk of stroke. Many people with diabetes also have high blood pressure, high blood cholesterol and are overweight. This increases their risk even more. If you have diabetes, work closely with your doctor to manage it.

Carotid or other artery disease — The carotid arteries in your neck supply blood to your brain. A carotid artery narrowed by fatty deposits from atherosclerosis (plaque buildups in artery walls) may become blocked by a blood clot. Carotid artery disease is also called carotid artery stenosis.

Peripheral artery disease is the narrowing of blood vessels carrying blood to leg and arm muscles. It is caused by fatty buildups of plaque in artery walls.

Atrial fibrillation — This heart rhythm disorder raises the risk for stroke. The heart’s upper chambers quiver instead of beating effectively, which can let the blood pool and clot. If a clot breaks off, enters the bloodstream and lodges in an artery leading to the brain, a stroke results.

Other heart disease — People with coronary heart disease or heart failure have a higher risk of stroke than those with hearts that work normally. Dilated cardiomyopathy (an enlarged heart), heart valve disease and some types of congenital heart defects also raise the risk of stroke.

Transient ischemic attacks (TIAs) — TIAs are “warning strokes” that produce stroke-like symptoms but no lasting damage. Recognizing and treating TIAs can reduce your risk of a major stroke. It is very important to recognize the warning signs of a TIA or stroke.

Certain blood disorders — A high red blood cell count thickens the blood and makes clots more likely. This raises the risk of stroke. Doctors may treat this problem by removing blood cells or prescribing “blood thinners”.

Sickle cell disease (also called sickle cell anemia) is a genetic disorder that mainly affects African Americans. “Sickled” red blood cells are less able to carry oxygen to the body’s tissues and organs. They also tend to stick to blood vessel walls, which can block arteries to the brain and cause a stroke.

High bood cholesterol — A high level of total cholesterol in the blood (240 mg/dL or higher) is a major risk factor for heart disease, which raises your risk of stroke. Recent studies show that high levels of LDL (“bad”) cholesterol (greater than 100 mg/dL) and triglycerides (blood fats, 150 mg/dL or higher) increase the risk of stroke in people with previous coronary heart disease, ischemic stroke or transient ischemic attack (TIA). Low levels (less than 40 mg/dL) of HDL (“good”) cholesterol also may raise stroke risk.

Physical inactivity and obesity — Being inactive, obese or both can increase your risk of high blood pressure, high blood cholesterol, diabetes, heart disease and stroke. So go on a brisk walk, take the stairs, and do whatever you can to make your life more active. Try to get a total of at least 30 minutes of activity on most or all days.

Excessive alcohol — Drinking an average of more than one alcoholic drink a day for women or more than two drinks a day for men can raise blood pressure and may increase risk for stroke.

Some illegal drugs — Intravenous drug abuse carries a high risk of stroke. Cocaine use has been linked to strokes and heart attacks. Some have been fatal even in first-time users.

The internal organs most likely to be weakened by these factors are the Kidney and the Spleen, causing deficiencies of Chi, Blood, and Yin. Deficiencies of Chi, Blood, or Yin permit the body to be overwhelmed by the pathological factors of Wind, Phlegm, Fire, and Stasis, resulting in such stroke-related patterns as Liver Yang Rising. Stasis of Chi or Blood, Phlegm combining with Fire, Liver Wind, or Wind in the Meridians.

What are the symptoms before and after Stroke?

Most of the symptoms for Stroke are reflected on prevailing diseases described under the above Disease Factors. In TCM the Chinese pattern refers to wind dampness and Qi stagnant as reflected by the tongue having thick coating. The after-effects of Stroke are speech-difficulty, speaking speech-impaired, walking- difficulty, limbs-debility, limbs-numb, numbness, joints-numbness, joints-pain, muscle-spasms, headache-dull, dizziness, pain-flank (stabbing pain), epigastrium-pain, epigastnum-distention, abdomen-distention, borborygmus, stool-diarrhea, vomiting, hemiplegia, knees-weak, arm pit-cold (elderly), lower back-weakness, Beii Palsy, headache, spasms, phlegm, chest-cold (elderly).


STROKE – THE ATTACK

Stroke is usually associated with other underlying health problems, including narrowing of the arteries, heart disease or high blood pressure. Diabetes increases the risk of stroke too as it weakens cerebral blood vessels that can cause bleeding into the brain.

Most strokes occur when a local blood clot blocks one of the cerebral arteries or when a blood clot that occurred in the heart is pumped out to lodge in a blood vessel of the brain. In other cases the problem is the result of a burst blood vessel hemorrhaging into the brain. Without an adequate supply of oxygen and glucose-  transported in the blood - brain and tissue die

In general, damage to the right side of the brain can cause paralysis on the left of the body, impaired spatial perception and loss of memory. Damage to the left hemisphere of the brain is more likely to result in paralysis of the right side of the body, speech impairment and difficulty in understanding and remembering words.

Not all strokes cause such serious damage. A “mini-stroke” or TIA (transient ischemic attack) has all the hallmark of a full blown stroke, but the effects are temporary and subside completely within 24 hours, leaving no trace. Some patients are not even aware of what happened, but recognizing and treating a TIA is essential it can be warning of more serious trouble ahead.

STRO-CARE is a specially prescribed formulation that consists of herbs that have healing properties against stroke symptoms and grants relief. Herbs like Radix Polygonum Multiflorum, Rhizoma Ligusticum Chuanxiong, Rhizoma Atractylodes Macrocephala, Semen Ziziphi Spinosae, Ramulus Cinnamomi Cassia, Fructus Lycii Babarum and Fructus Psoraleae Corylifolia have traditionally been used for stroke problems.

1) Radix Polygonum Multiflorum: Tonifies the liver and the kidneys and replenishes their vitality; treats fatty liver, increases red blood cells and reduces blood fats; exerts same effect as adrenocortical hormone; nourishes blood; for aching backs and knees; treats tiredness and exhaustion; protects heart from free radical damage.

 

Polygonum Multiflorum: Research shows that "The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 microM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity" (IC50, 0.38 microM).The radical scavenging effects of stilbene glucosides from Polygonum multiflorum” Arch Pharm Res 2002 Oct;25(5):636-9.

2) Rhizorna Ligustic Chuanxiong: Invigorates blood circulation and promotes the flow of vital energy.

a) Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. The present study reported, for the first time, the pharmacokinetics of ligustilide, administered in its pure form and in an herbal extract, in rats. After i.v. administration of pure ligustilide, it was distributed extensively (Vd, 3.76 ± 1.23 l/kg) and eliminated rapidly (t1/2, 0.31 ± 0.12 h). The i.v. clearance (CL) of ligustilide after Chuanxiong extract administration was significantly higher than that dosed in its pure form [CL, 20.35 ± 3.05 versus 9.14 ± 1.27 l/h/kg, p < 0.01; area under the curve (AUC), 0.79 ± 0.10 versus 1.81 ± 0.24 mg · h/l, p < 0.01], suggesting significant interaction between ligustilide and components present in the extract. Dose-dependent pharmacokinetics was observed after i.p. administration, and a significantly higher dose-normalized AUC (1.77 ± 0.23 mg · h/l) at 52 mg/kg was obtained than that at 26 mg/kg (0.93 ± 0.07 mg · h/l, p < 0.05). Oral bioavailability of ligustilide was low (2.6%), which was partly because of extensive first-pass metabolism in the liver. Seven metabolites of ligustilide were identified, and three of them were unequivocally characterized as butylidenephthalide, senkyunolide I, and senkyunolide H. These three compounds also occurred naturally in the herb and were reported to be bioactive. “Pharmacokinetics and Metabolism of Ligustilide, a Major Bioactive Component in Rhizoma Chuanxiong, in the Rat.” Drug Metabolism and Disposition DOI: 10.1124/dmd.107.017707

b) The purpose of the present study was to investigate the effect of ligustilide on vasodilatation in rat mesenteric artery and the mechanisms responsible for it. Isometric tension of rat mesenteric artery rings was recorded by a sensitive myograph system in vitro. The results showed that ligustilide at concentrations more than 10 μM relaxed potassium chloride (KCl)-preconstricted rat mesenteric artery in a concentration-dependent manner. The vasodilatation effect of ligustilide was not dependent on endothelium. Ligustilide rightwards shifted concentration-response curves induced by KCl, calcium chloride (CaCl2), noradrenaline (NA) or 5-hydroxytryptamine (5-HT) in a non-parallel manner. This suggests that the vasodilatation effects were most likely via voltage-dependent calcium channel (VDCC) and receptor-operated calcium channel (ROCC). Propranolol, glibenclamide, tetraethylammonium and barium chloride did not affect the vasodilation induced by ligustilide, showing that p-adrenoceptor, ATP sensitive potassium channel, calcium-activated potassium channel and inwardly rectifying potassium channel were not involved in the vasodilatation. Ligustilide concentration-dependently inhibited the vasoconstriction induced by NA or CaCl2 in Ca2+-free medium, indicating that the vasodilatation relates to inhibition of extracellular Ca2+ influx through VDCC and ROCC, and intracellular Ca2+ release from Ca2+ store. Since caffeine-induced contraction was inhibited by ligustilide, inhibition of intracellular Ca2+ released by ligustilide occurred via the ryanodine receptors. Our results suggest that ligustilide (from Rhizoma Ligusticum Chuanxiong) induces vasodilatation in rat mesenteric artery by inhibiting the VDCC and ROCC, and receptor-mediated Ca2+ influx and release. “Ligustilide induces vasodilatation (relaxes the smooth muscle in blood vessels, a key factor for erection to take place: this is how Viagra works) via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release.” Vascular Pharmacology ISSN 1537-1891 2006, vol. 45, n 3, pp.171-176

c) Tetramethylpyrazine (TMP) and salvianolic acid B (SAB) are effective ingredients of Rhizoma Ligustici chuanxiong Hort. and Radix Salviae miltiorrhizae Bge., accordingly. The inhibitive effects of TMP, SAB and their combination on shear-induced platelet aggregation (SIPA) were investigated in the present study. SD rats were used as blood donors to collect anticoagulated blood, the concentration of platelet-rich-plasma (PRP) was adjusted to 5×105 μl. HAAKE rheometer RS 600 with sensor C60/0.5° was used as shear generator. Different doses of TMP and SAB and their combinations were added to the PRP. After constant shear of 15 Pa at 37°C for 360 seconds, PRP was transferred to a platelet aggregometer and SIPA was determined by turbidity. SIPA was inhibited by TMP and SAB in a dose-dependent manner. SIPA was decreased from 48.6±4.6% of the control to 12.5±2.1% in the presence of TMP (1.46 mM) and SAB (10 μM) (P<0.0001). In conclusion, TMP and SAB have additive effects on inhibiting platelet aggregation induced by high shear stress. “Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B, active component of Rhizoma Ligustici Chuanxiong”. Clinical Hemorheology and Microcirculation Vol. 31, Number 2/2004 Pages 97-103

3) Rhizoma Atractylodis Macrocephalae: Tones up energy and strengthens the spleen. Protects the liver, promotes urination and reduces blood sugar.

4) Semen Ziziphi Spinosae: Nourishes blood and the liver. Traditional use to placate the heart and calm the spirit.

5) Ramulus Cinnamoni Cassia: Warms and clears up blood channels and promotes blood circulation for amenorrhoea (cessation of normal menstruation) and angina pectoris.

6) Fructus Lycii Barbarum: Replenishes the vital essences of the liver and the kidneys

7) Fructus Psoraleae Corylifolia: Warms up the kidneys to reinforce the vital functions of the sexual organs.

a) Clinical studies by western scientists have shown that Radix Angelicae Sinensis, Radix Rubiae and Fructus Psoraleae can improve kidney functions. The results before and after treatment showed an evident difference, with low function before treatment and normal after treatment. Forty-one children with idiopathic thrombocytopenic purpura (ITP) were reported in this paper. Of all, 36 with petechia and ecchymosis, 28 with nasal hemorrhage, 5 with hematochezia and 1 with subcutaneous hematoma. According to the TCM differentiation, 24 and 17 of all belonged to the type of impairment of Yin due to blood-heat and both deficiencies of Qi and tonifying Kidney and its basic prescriptions were: dried Radix Rehmanniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Radix Rubiae, Fructus Psoraleae, stir-frying Radix Astragali, Semen Cuscutae, Caulis Spatholob; Chinese Jujubae, Radix et Rhizoma Rhei. The average treating duration was 5.02 months. Results: 24 cases cured, 6 recovered, 10 improved, 1 failed, with a total effective rate of 97.6%. 22 of the cured were followed-up without recurrence in average 10.4 months after withdrawal. In 32 cases, the thrombocyte aggregative function was tested with ADP induction, meanwhile in 20 of 32 cases aggregation with adrenaline induction was tested. The results before and after treatment showed an evident difference, with low function before treatment and normal after treatment. It is concluded that the replenishing Qi and tonifying Kidney may have a better effect on both acute and chronic children ITP without recurrence after withdrawal. “Idiopathic thrombocytopenic purpura in children treated with replenishing qi and tonifying kidney and the changes in thrombocyte aggregative function” Zhong Xi Yi Jie He Za Zhi. 1991 Jan;11(1):14-6, 3.

b) Clinical studies by western scientists have shown that Psoralea corylifolia stimulates bone formation. Osteoblastic differentiation bioassay and its application to investigating the activity of fractions and compounds from Psoralea corylifolia L” A cell differentiation bioassay measuring alkaline phosphatase activity was developed using osteoblast-like UMR 106 cell line as a model. The effect of fractions and compounds of Psoralea corylifolia L. extract on osteoblastic differentiation was investigated. The fractions or compounds were co-cultured with cells for 48 h, the cellular ALP activity was then measured. The crude ethanol extract of Psoralea corylifolia L. increased ALP activity by 39.5% at a concentration of 0.1 mg/ml, and the activity was concentrated in the ethyl acetate fraction, which produced a maximum ALP activity increase of 38.2%. A significant activity was observed for a flavonoid, corylin, providing 30.0% increment in ALP. These effects suggest that Psoralea corylifolia L. extract, its ethyl acetate fraction and corylin would stimulate bone formation. “Osteoblastic differentiation bioassay and its application to investigating the activity of fractions and compounds from Psoralea corylifolia L.” School of Pharmacy, Shenyang Pharmaceutical University 103 Wenhua Road, Shenyang, 110016, China ISSN:0031-7144 Vol. 58 Issue 12

 

Eminent scientists of well-known universities have scientifically researched and  proved the incredible efficacy of these natural herbs used by us. We only bring to you formulas that can say something for themselves.

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