Nutrihuang.com TCM and Incontinence for OEM
 
 
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Traditional Chinese Medicine for Incontinence has Scientific Backing

It is a condition where the sufferer frequently experience small amounts of urine leak. These leaks can occur during coughing or laughter. Others feel the urge to urinate and cannot control it. The loss of bladder control can be very embarrassing. The loss of bladder control is not a normal part of aging. Many people with bladder control problems hide the problem from everyone, even from their doctor. There is no need to do that. In most cases loss of bladder control can be treated. It might even be cured. If you are having bladder control problems, don't suffer in silence. What is the real problem?

The Endocrine System

The major function of of the endocrine system is to produce hormones. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathyroids, adrenals, pineal body, and the reproductive glands, which include the ovaries and testes. The body's organs also produce hormones but not as much as the endocrine system.

Even though the pituitary gland is no bigger than a pea, it is considered the most important part of the endocrine system. It's often called the "master gland" because it makes hormones that control several other endocrine glands. The body cannot function without hormones. Once produced they are sent to various parts of the body to keep the organs and the system function in a health state.

Unaware to us, the glands of the endocrine system and the hormones they release influence almost every cell, organ, and function of our bodies. This only shows how important the endocrine system is to us in supporting the human infrastructure. The endocrine system is instrumental in regulating the healthy function of the five organs, growth and development, tissue function, and metabolism, as well as sexual function and reproductive processes. Broadly speaking, the endocrine system ensure the cell system and its growth functions like clock work. Even though faster processes like breathing and body movement are monitored by the nervous system, the nervous system cannot function properly if the endocrine system goes hare wire. Even though the nervous system and endocrine system are separate systems, they are not mutually exclusive.

Bad Neuropeptides and Degenerative Diseases

Long ago scientists do not know or understand the functions of free radicals. It was in recent times that the damaging effects of free radical was fully understood. If it is not controlled, this toxic substances can create problems within our body. In the same manner scientists, once upon a time, did not understand the functions of the enzyme, prolyl endopeptidase or PEP. Research by western scientists have shown that PEP is a proteolytic enzyme commonly found in the body. It is thought that it serves no useful functions but just exist within our body. It was thought that they were just some substances floating in the body's extracellular space.

Less then 10 years ago, it was discovered by scientists that these enzymes are no gentlemen!! In fact it was discovered that they can do far more damages to the body then free radicals. In 2002, clinical research by western scientists  found out that this commonly found enzyme, bad neuropeptides (PEP) gobbles up good neuropeptides (hormones). Discovering them is one thing, controlling them is another. This destructive enzyme cannot be destroyed by the normal antioxidants that is commonly found in fruits and herbal products.

Good Neuropeptides and Degenerative Diseases

Neuropeptides are neuroactive molecules (a special subgroup of hormones) that help to coordinate, integrate, and regulate physiological processes in our body. They act as neurohormones, neurotransmitters, and/or neuromodulators and they help to maintain physiological homeostasis and influence important behavioral patterns. The health of our body depends on the efficient functions of our glands and the hormones. It is a very complicated and complex network. But if their work is disrupted or interfered or compromised then the body will eventually show signs of dysfunction  or complains. Our organs can begin to show signs of rundown.

Let us look at the complex and intricate relationship of these glands. The hypothalamus gland produces Thyrotropin Releasing Hormone (TRH), a good neuropeptides. It is transported to the thyroid gland. The function of TRH is to control the production of TSH (thyrotropin-stimulating hormone). TSH regulates the endocrine functions of the thyroid which regulates many other things. TSH is produced by the pituitary gland. The pituitary gland itself produces many types of hormone. Its functions is influence by the hypothalamus gland through TRH.

The production and secretion of pituitary hormones is influenced by the hypothalamus gland who relays information sensed by the brain (such as environmental temperature, light exposure patterns, and feelings) to the pituitary. What does the pituitary gland do?

 

The tiny pituitary is divided into two parts: the anterior lobe and the posterior lobe. The anterior lobe regulates the activity of the thyroid, adrenals, and reproductive glands. Among the hormones it produces are growth hormone, prolactin, thyrotropin and corticotropin. The job of each hormone are:

  • growth hormone stimulates the growth of bone and other body tissues and plays a role in the body's handling of nutrients and minerals

  • prolactin activates milk production in women who are breastfeeding
  • thyrotropin stimulates the thyroid gland to produce thyroid hormones
  • corticotropin stimulates the adrenal gland to produce certain hormones
  • endorphins chemicals act on the nervous system to reduce sensitivity to pain

The anterior pituitary also secretes hormones to signal the ovaries and testes to make sex hormones. It also controls ovulation and the menstrual cycle in women.

 

The anterior pituitary gland controls the thyroid gland through TSH hormones. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3) which control the rate at which cells burn fuels from food to produce energy. As the level of thyroid hormones, T3 and T4, increases in the bloodstream, so does the speed at which chemical reactions occur in the body. Thyroid hormones also play a key role in bone growth, the development of the brain and central nervous system. In short if TRH is affected, so will TSH ( because TRH controls the production of TSH) and so will the production of T3 and T4.

The posterior  pituitary releases antidiuretic hormone like vasopressin (a good neuropeptide), which helps control body water balance through its effect on the kidneys and urine output. It is synthesized in the hypothalamus and transported to the posterior pituitary and stored here. If the body water balance is affected then it would affect the "electrolyte" balance of the body. If the potassium and salt balance in the body system goes haywire, it would create a chain reaction of problems, creating a series of diseases.

So even though the pituitary gland is considered the most important gland in the endocrine system, the importance of the hypothalamus vis a vis its production of TRH and other hormones it produces could not be underestimated. The production and secretion of pituitary hormones is influenced by the hypothalamus gland. The hypothalamus gland produces TRH. TRH controls the production of TSH which is produced by the pituitary gland. TSH regulates the endocrine functions of the thyroid. So if the production or the health of TRH is affected, it would create a chain reaction of problems with our body.

The Hidden Enemy and Degenerative Diseases

Not too long ago they discover that our digestive system contains good bacteria that helps in our digestion. But they could be destroyed by bad bacteria that enters our digestive system. In the same manner for a long time, prolyl endopeptidase (PEP) was believed to be an inactivate neuropeptides that existed in the extracellular space. But it was discovered that they destroy the good neuropeptides like vasopressin, substance P and TRH. It was discovered that the preventive destruction of good neuropeptides like vasopressin "kidney hormone" and thyrotropin-releasing hormone "brain hormone" (TRH) by PEP (prolyl endopeptidase) inhibitors can prevent the degeneration of the brains, the central nervous system and the kidneys.

Substance P: In neuroscience, Substance P is a neuropeptide: a short-chain polypeptide that functions as a neurotransmitter and as a neuromodulator. Substance P is an 11-amino acid polypeptide with the sequence: Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met NH2. In the central nervous system, substance P has been associated in the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis (is the process by which neurons are created), respiratory rhythm, neurotoxicity, nausea / emesis and pain. If you notice carefully a person who suffers from Alzheimer disease would also have most of these problems.

Clinical studies by European scientists have shown that the destructions of good neuropeptides, TRH, vasopressin and substance P by bad neuropeptides, PEP, can be inhibited by PEP  inhibitors that can be found in Radix Linderae.

It was discovered that PEP enzymes can be commonly found in the brain, kidneys, liver, lungs and heart. Clinical studies by western scientists have shown the levels of tissue PEP activity were highest in kidney of adult rats. If uncontrolled, then the degradation activities of PEP would affect the functions of these organs, depending on the level of intensity of the activities found in each locality.

Long term consumption of formulated Radix Linderae can prevent the development of degenerative diseases caused by PEP through the control of its destructive activities. Most generative diseases starts with the dysfunction of the kidneys. That is why in TCM herbalism, kidneys is the get way to life. There is some truth in this if one understands the damaging work of PEP. PEP can damages the body in the same way free radicals do but far more destructive. Consumption of herbs to prevent and address the destructive effects of bad neuropeptides, PEP, is one way to prevent and control the development of degenerative diseases. That is why those who knows how to maintain their health are active and  mentally alert even in their old age.

Anatomy of the Kidney

The kidneys are paired reddish-brown organs located one on each side of the vertebral column and on the posterior wall of the abdominal cavity. The adrenal glands are situated on the superior portion of each kidney. Being approximately 11 cm. long, they extend down from the level of the twelfth thoracic to the third lumbar vertebra. The right kidney sits slightly lower than the left because of the presence of the liver.

The kidney proper is composed of a cortex or outer layer; the medulla which is located deep to the cortex and consists of up to 18 triangular renal pyramids. The renal pelvis is the papilla of each pyramid projecting into a funnel-shaped minor calyx. The major calyces unite to form the renal pelvis which is the expanded upper end of the ureter. The urine passes as droplets from tiny pores in the papillae into the renal pelvis and finally the ureter, which carries it to the urinary bladder.

The urinary tract is made up of four parts:

  • Kidneys, which produce urine

  • Ureters, which take urine to the bladder

  • The bladder, where urine is stored

  • The urethra, which carries urine out of the body

Types of Incontinence

There are 3 types of urinary incontinence:

  1. Stress
  2. Urge/Overactive
  3. Functional

Stress incontinence: You can loose urine when you exercise, laugh, cough, sneeze or lift heavy objects.

Urge or overactive incontinence: This happens when you can't hold urine for very long. You don't reach the toilet in time.

Functional incontinence: It causes leaks to happen because of health problems

 

Causes of Urinary Incontinence and Frequent Urination

  • Infections in the urinary tract can make you lose bladder control.

  • Some drugs can also cause bladder problems such as diuretics

  • Bladder muscles might be weak or overactive.  

  • Nerves that control the bladder might be damaged.

Other Causes:

When the kidney is suffering from coldness (in TCM terminology the renal pelvis has caught a cold) the person suffers from frequent urination and urinary incontinence. It is a symptom that the person is slowing going to develop degenerative diseases. But if the person suffers from weak kidneys then he only suffers from frequent urination. Therefore in modern day term this weakness could be due to the activities of PEP (prolyl endopeptidase). It is a sign that bad neuropeptides (PEP) are slowly gobbling up the important hormones that is essential for maintaining good health. Usually the first sign of degeneration is manifested through the kidneys. That is why herbalists use awesome terminology to describe the kidneys like:

  • The Gate of Vitality

  • The Root of Yin and Yang

  • Kidneys govern growth, maturation and procreation

  • Kidneys produce skill and house the will

  • Kidneys hold the essence

  • Kidneys govern the bones and the marrow

Symptoms of Cold Kidneys are:

  • Lower back ache
  • Frequent urination
  • Uncontrollable urination

If not treated it could lead to other problems like:

  • Urinary tract infections
  • Sleeping problems
  • Less social and sexual activity
  • Loss of self-esteem
  • Depression

In the long-term the person could develop degenerative diseases like weak heart, weak kidneys, brain degeneration and Alzheimer disease. Alzheimer disease is a progressive degenerative disease of the brain. The symptoms are impairment of memory and dementia manifested by confusion, visual-spatial disorientation, inability to calculate, and deterioration of judgment; delusions and hallucinations may occur. The most common degenerative brain disorder, Alzheimer disease makes up 70% of all cases of dementia. This is the extreme case of brain degeneration. Not all reach that stage. Just as everybody needs to detox the body but not everybody develop cancer which is an extreme case of accumulation of poison in the body. Everybody suffers from some of the symptoms of Alzheimer disease like forgetfulness, mild confusion and slowness of the brain (not alert and slow to response) when they grow old but not every case develop into Alzheimer.

Treatment

The treatment depends on what kind of bladder problem you have. It also depends on the cause. Here are some treatments you could get:

  • Drugs
  • Surgery
  • Devices such as a patch, plug, implant

If the problem is not due to infection but due to dysfunction of the renal pelvis then herbs must be taken to warm up the kidneys. Research has show that herbs like Radix Linderae, Fructus Psoraleae, Fructus Corni, Fructus Rubi and Radix Angelicae Sinensis are beneficial for treating such problem.

Radix Linderae:

1) Clinical studies by western scientists have shown that Radix Linderae contains PEP (Prolyl endopeptidase) inhibitors that can improve the functions of proline-containing neuropeptides, e.g., vasopressin "kidney hormone", substance P, and thyrotropin-releasing hormone "brain hormone" (TRH). These  neuropeptides  are involved in the processes of learning and memory, renal and other physiological activities.    (Neuropeptides are neuroactive molecules which helps to coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns.) 86408

2) Clinical studies by European scientists have shown that the destructions of neuropeptides, thyrotrophin-releasing hormone (TRH) and arginine-vasopressin (AVP), by prolyl endopeptidase can be inhibited by PEP (Prolyl endopeptidase) inhibitors.  PEP (Prolyl endopeptidase) inhibitors can be found in plants like Radix Linderae 69566

3) Research scientists from Japan said Lindera strychnifolia, a medicinal plant, has long been used for the treatment of cardiac, renal and rheumatic diseases. 81648

4) Clinical studies by western scientists have shown that the extract of Radix Linderae (RL) slowed down the progression of diabetic nephropathy (disease of the kidney). It resulted in a better renal function as evaluated by creatinine clearance (Ccr) and serum creatinine. Kidneys of the RL extract-treated group showed glomeruli with greater area and cell population etc. 25389

5) Research scientists from Japan confirmed Lindera strychnifolia has analgesic and anti-inflammatory action. 72507

6) Clinical studies by western scientists have shown the levels of tissue prolyl endopeptidase (PEP) activity were highest in kidney of adult rats. 1849/90

7) Clinical studies by western scientists have shown that Prolyl endopeptidase is a proteolytic enzyme (enzyme that digest protein) which could have a neuropeptide catabolising (destructive) role in the central nervous system. The activity of the enzyme was higher in the human than in the rat brain. Prolyl endopeptidase enzyme are also found in the kidneys. 92464

Fructus Psoraleae: Clinical studies by western scientists have shown that Radix Angelicae Sinensis, Radix Rubiae and Fructus Psoraleae can improve kidney functions. The results before and after treatment showed an evident difference, with low function before treatment and normal after treatment. 54885

Fructus corni: Clinical results demonstrate that Fructus corni can promote a protective antioxidant defense state by affecting some important enzymatic and nonenzymatic oxidant-scavenging systems and may thus be useful for the prevention or treatment of disorders associated with oxidative damage in the kidneys.  31(2):221-5

Radix Angelicae Sinensis: Clinical studies by western scientists have shown that Radix Angelicae Sinensis has hematopoietic effect (formation of blood cellular components) on person suffering from chronic renal failure. TCM says blood can be nourish and circulation can be improved. Therefore result showed that Radix Angelicae Sinensis improves kidney functions. 30986

Thanks to growing trust in herbal treatments survival rates have improved over the years. Herbal formulations to treat various types of liver problems has proven to be safe and very effective without any side effects. When allopathic science failed, more and more people have to turn to trustworthy alternative source. It was desperation that saves them.