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1. Herba Schizonepetae
Function of the herb:
-
it acts on lungs and liver channel
-
inducing sweats, dispelling exopathogens, dispersing
pathogenic wind and arresting bleeding.
1)
Scientific research showed that Chinese herbs are
effective in promoting lipolysis (breakdown of fat
stored in fat cells). "Chinese herbal medicines,
Forsythiae Fructus, Glycyrrhizae, Rheum Palmatum,
Gardeniae Fructus and Schizonepetae Spica
containing 3, 18 and 8 components,
respectively, have since long been used as an
anti-inflammatory, antipyretic, choleretic and diuretic
agent for liver disorders and jaundice, as an
anti-obesity agent, a hypocholesterolemic agent for
liver disorders and a therapeutic and/or preventive
agent for cholesterol gallstone disease with
hypertriglycerid-emia in China and Japan, respectively.
In the present study, we investigated the effects of
these five herbal medicines in young male mice fed a
high-fat diet. Plasma levels of lipids and the numbers
of the fatty droplets in the liver cytoplasm were
markedly lowered by the diets supplemented with three
herbal medicines. The liver weights and the body growth
were reduced by the diet supplemented with Chinese herbs,
which slightly affected the concentrations of total
protein, albumin, creatinine or calcium, and the
activity of lactate dehydrogenase. Thus, they are effective in the
activities of anti-obesity, anti-hyperlipidemia and
anti-hyperlipids in liver cytoplasm, when used
carefully”. “Effects of
five Chinese herbal medicines on plasma and liver
lipids in mice fed a high-fat diet.”
Journal
of Ethnopharmacology
Volume 109, Issue 2,
19 January 2007, Pages 236-240
2.
Gardeniae Fructus
Function of the herb:
-
antipyretic and sedative
-
chologogue for acute icteric hepatitis
-
antifebrile and hemostatic
1)
Research by Korean scientists shows that Gardeniae
Fructus can reduce blood fat.
Research shows that the hypolipidemic activity of GF and its component crocin
may be due to the inhibition of pancreatic lipase and
crocin, and its metabolite, crocetin, can improve
hyperlipidemia. Source: “Antihyperlipidemic
(reduce blood fat)
effect of crocin isolated from the fructus of Gardenia
jasminoides and its metabolite Crocetin.”
Biol Pharm Bull. 2005
Nov;28(11):2106-10
2)
Research by Japanese scientists shows that Gardeniae
Frustus and Rheum Palmatum promotes breaking down of lipids
(e.g. fats and cholesterol).
Pharmacological examination was
made on bile secretion in rats, the most
representative preparation for jaundice in Chinese
medicine, and on each of its three constituent crude
drugs (Gardeniae Fructus, Artemisiae Capillaris and
Rheum Palmatum). The extract of Gardeniae Fructus hardly
increased bile secretion, while genipin (found in
Gardeniae Fructus), an agiycone of geniposide which is
present in this crude drug, markedly increased it
“Pharmacological Studies of Gardeniae Fructus. II.
Contribution of the Constituent Crude Drugs of
Choleretic Activity in Rats”.
Journal of the Pharmaceutical Society of Japan
Vol.96, No.2(19760225)
pp. 147-153
3)
“This article discusses the
effects of Fructus Gardeniae extract on hepatic
function. Fructus Gardeniae extract manifested no
hepatotoxic effects on rats, as shown by alkaline
phosphatase, aspartate aminotransferase, and lactate
dehydrogenase studies. Fructus Gardeniae extract failed
to activate the UDP-glucuronyltransferase system;
whereas in hyperbilirubinemic state the enzyme was
activated, presumably by substrate induction. Fructus
Gardeniae extract increased the activity of UDP-glucose
dehydrogenase, which would result in an increase in
availability of UDP-glucuronic acid intracellularly. BSP
clearance study showed an unexpected impairment of
hepatic uptake of the dye after extract treatment. The
action mechanism involved in lowering of serum bilirubin
level by Fructus Gardeniae extract may well be complex;
it is probably acting on a locus other than glucuronyl
transferase.”
Effects of Fructus Gardeniae Extract on Hepatic Function
The American Journal of Chinese Medicine (AJCM) 1977 Vol:
5 Issue: 3/4 (1977) Page: 241 - 255
3. Radix Glycyrrhiza Glabra
Function of the herb:
-
Used to invigorate functions of the heart and spleen
for the treatment of symptoms due to deficiency of
vital energy of these viscera
-
Cleanse and protect the liver
-
Promotes production of red blood cells
-
Invigorates the function of the heart and the spleen
-
Improves the vital energy
-
Improves the immune system
1)
Research by Japanese scientists showed that Glycyrrhizae
Radix (GR) extract, Forsythiae Fructus (FF) extract and
Herbal Schizonepetae (HS) extract reduces the body
weight in mice after 8 weeks through lipolysis
(breakdown of fat stored in fat cells).
Source:
“Thermogenic, anti-obesity effects of Chinese herbs in
MSG-obese mice.”
Int-J-Obes-Relat-Metab-Disord. 1995 Oct; 19(10): 717-22
2)
Research
showed that Chinese herbs are effective in the
activities of anti-obesity, anti-hyperlipidemia and
anti-hyperlipids in liver cytoplasm.
"Effects
of Chinese herbal medicines on plasma and liver lipids
in mice fed a high-fat diet".
Journal of
Ethnopharmacology
Volume 109, Issue 2,
19 January 2007, Pages 236-240.
4.
Forsythiae Fructus
Functions of
the herb:
-
It has antipyretic and anti-inflammatory agent
Research by
Japanese scientists has shown that this group of herbs
Forsythiae Fructus, Glycyrrhizae Rhei Rhizoma, Gardeniae
Fructus and Schizonepetae Spica can be used to reduce
weight in humans.
Their blood triglycerides levels
decreased significantly following administration of
these herbs. The decrease in appetite was considered to
be due to activation of the adrenaline. BETA.3 receptor
as well as due to the psychotropic actions (affecting
the mind or mood or other mental processes) of Gardeniae
Fructus. Source:
“The Effect
of Chinese herbs on Weight Reduction in Humans.”
Japanese Journal of Oriental Medicine
VOL.56;NO.6;PAGE.933-939(2005)
5. Rheum Palmatum
Functions of
the herb:
-
used as an effective digestive
-
effective for promoting gastrointestinal peristalsis
-
promote bowel movement
-
benefit gall bladder and reduce jaundice
-
increase and protects blood platelets
1)
Research showed that Chinese herbs can be used to treat
obesity. "Chinese herbal medicines,
Forsythiae Fructus, Glycyrrhizae, Rheum Palmatum,
Gardeniae Fructus and Schizonepetae Spica
containing 3, 18 and 8 components,
respectively, have since long been used as an
anti-inflammatory, antipyretic, choleretic and diuretic
agent for liver disorders and jaundice, as an
anti-obesity agent, a hypocholesterolemic agent for
liver disorders and a therapeutic and/or preventive
agent for cholesterol gallstone disease with
hypertriglycerid-emia in China and Japan, respectively.
In the present study, we investigated the effects of
these five herbal medicines in young male mice fed a
high-fat diet. Plasma levels of lipids and the numbers
of the fatty droplets in the liver cytoplasm were
markedly lowered by the diets supplemented with three
herbal medicines. The liver weights and the body growth
were reduced by the diet supplemented with Dai-saiko-to,
which slightly affected the concentrations of total
protein, albumin, creatinine or calcium, and the
activity of lactate dehydrogenase. Thus, they are effective in the
activities of anti-obesity, anti-hyperlipidemia and
anti-hyperlipids in liver cytoplasm, when used
carefully”. “Effects of
five Chinese herbal medicines on plasma and liver
lipids in mice fed a high-fat diet.”
Journal
of Ethnopharmacology
Volume 109, Issue 2,
19 January 2007, Pages 236-240
2)
Research by Japanese scientists shows that Gardeniae
Frustus and Rheum Palmatum promotes breaking down of lipids
(e.g. fats and cholesterol).
Pharmacological examination was
made on bile secretion in rats of "Inchinkoto", the most
representative preparation for jaundice in Chinese
medicine, and on each of its three constituent crude
drugs (Gardeniae Fructus, Artemisiae Capillaris and
Rheum Palmatum). The extract of Gardeniae Fructus hardly
increased bile secretion, while genipin (found in
Gardeniae Fructus), an agiycone of geniposide which is
present in this crude drug, markedly increased it
“Pharmacological Studies of Gardeniae Fructus. II.
Contribution of the Constituent Crude Drugs of
Choleretic Activity in Rats”.
Journal of the Pharmaceutical Society of Japan
Vol.96, No.2(19760225)
pp. 147-153
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